Pathological gambling in Parkinson's disease: subthalamic oscillations during economics decisions.
Identifieur interne : 000850 ( Main/Exploration ); précédent : 000849; suivant : 000851Pathological gambling in Parkinson's disease: subthalamic oscillations during economics decisions.
Auteurs : Manuela Rosa [Italie] ; Manuela Fumagalli ; Gaia Giannicola ; Sara Marceglia ; Claudio Lucchiari ; Domenico Servello ; Angelo Franzini ; Claudio Pacchetti ; Luigi Romito ; Alberto Albanese ; Mauro Porta ; Gabriella Pravettoni ; Alberto PrioriSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aged, Decision Making (physiology), Deep Brain Stimulation, Electrodes, Implanted, Female, Gambling (complications), Gambling (physiopathology), Gambling (psychology), Humans, Male, Membrane Potentials (physiology), Middle Aged, Parkinson Disease (complications), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson Disease (therapy), Risk-Taking, Subthalamic Nucleus (physiopathology).
- MESH :
- complications : Gambling, Parkinson Disease.
- physiology : Decision Making, Membrane Potentials.
- physiopathology : Gambling, Parkinson Disease, Subthalamic Nucleus.
- psychology : Gambling, Parkinson Disease.
- therapy : Parkinson Disease.
- Adult, Aged, Deep Brain Stimulation, Electrodes, Implanted, Female, Humans, Male, Middle Aged, Risk-Taking.
Abstract
Pathological gambling develops in up to 8% of patients with Parkinson's disease. Although the pathophysiology of gambling remains unclear, several findings argue for a dysfunction in the basal ganglia circuits. To clarify the role of the subthalamic nucleus in pathological gambling, we studied its activity during economics decisions. We analyzed local field potentials recorded from deep brain stimulation electrodes in the subthalamic nucleus while parkinsonian patients with (n = 8) and without (n = 9) pathological gambling engaged in an economics decision-making task comprising conflictual trials (involving possible risk-taking) and non conflictual trials. In all parkinsonian patients, subthalamic low frequencies (2-12 Hz) increased during economics decisions. Whereas, in patients without gambling, low-frequency oscillations exhibited a similar pattern during conflictual and non conflictual stimuli, in those with gambling, low-frequency activity increased significantly more during conflictual than during non conflictual stimuli. The specific low-frequency oscillatory pattern recorded in patients with Parkinson's disease who gamble could reflect a subthalamic dysfunction that makes their decisional threshold highly sensitive to risky options. When parkinsonian patients process stimuli related to an economics task, low-frequency subthalamic activity increases. This task-related change suggests that the cognitive-affective system that drives economics decisional processes includes the subthalamic nucleus. The specific subthalamic neuronal activity during conflictual decisions in patients with pathological gambling supports the idea that the subthalamic nucleus is involved in behavioral strategies and in the pathophysiology of gambling.
DOI: 10.1002/mds.25427
PubMed: 23554027
Affiliations:
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Clinico per la Neurostimolazione, le Neurotecnologie ed i Disordini del Movimento, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Fumagalli, Manuela" sort="Fumagalli, Manuela" uniqKey="Fumagalli M" first="Manuela" last="Fumagalli">Manuela Fumagalli</name></author><author><name sortKey="Giannicola, Gaia" sort="Giannicola, Gaia" uniqKey="Giannicola G" first="Gaia" last="Giannicola">Gaia Giannicola</name></author><author><name sortKey="Marceglia, Sara" sort="Marceglia, Sara" uniqKey="Marceglia S" first="Sara" last="Marceglia">Sara Marceglia</name></author><author><name sortKey="Lucchiari, Claudio" sort="Lucchiari, Claudio" uniqKey="Lucchiari C" first="Claudio" last="Lucchiari">Claudio Lucchiari</name></author><author><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name></author><author><name sortKey="Franzini, Angelo" sort="Franzini, Angelo" uniqKey="Franzini A" first="Angelo" last="Franzini">Angelo Franzini</name></author><author><name sortKey="Pacchetti, Claudio" sort="Pacchetti, Claudio" uniqKey="Pacchetti C" first="Claudio" last="Pacchetti">Claudio Pacchetti</name></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name></author><author><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name></author><author><name sortKey="Pravettoni, Gabriella" sort="Pravettoni, Gabriella" uniqKey="Pravettoni G" first="Gabriella" last="Pravettoni">Gabriella Pravettoni</name></author><author><name sortKey="Priori, Alberto" 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Aged</term><term>Risk-Taking</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathological gambling develops in up to 8% of patients with Parkinson's disease. Although the pathophysiology of gambling remains unclear, several findings argue for a dysfunction in the basal ganglia circuits. To clarify the role of the subthalamic nucleus in pathological gambling, we studied its activity during economics decisions. We analyzed local field potentials recorded from deep brain stimulation electrodes in the subthalamic nucleus while parkinsonian patients with (n = 8) and without (n = 9) pathological gambling engaged in an economics decision-making task comprising conflictual trials (involving possible risk-taking) and non conflictual trials. In all parkinsonian patients, subthalamic low frequencies (2-12 Hz) increased during economics decisions. Whereas, in patients without gambling, low-frequency oscillations exhibited a similar pattern during conflictual and non conflictual stimuli, in those with gambling, low-frequency activity increased significantly more during conflictual than during non conflictual stimuli. The specific low-frequency oscillatory pattern recorded in patients with Parkinson's disease who gamble could reflect a subthalamic dysfunction that makes their decisional threshold highly sensitive to risky options. When parkinsonian patients process stimuli related to an economics task, low-frequency subthalamic activity increases. This task-related change suggests that the cognitive-affective system that drives economics decisional processes includes the subthalamic nucleus. The specific subthalamic neuronal activity during conflictual decisions in patients with pathological gambling supports the idea that the subthalamic nucleus is involved in behavioral strategies and in the pathophysiology of gambling.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><noCountry><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><name sortKey="Franzini, Angelo" sort="Franzini, Angelo" uniqKey="Franzini A" first="Angelo" last="Franzini">Angelo Franzini</name><name sortKey="Fumagalli, Manuela" sort="Fumagalli, Manuela" uniqKey="Fumagalli M" first="Manuela" last="Fumagalli">Manuela Fumagalli</name><name sortKey="Giannicola, Gaia" sort="Giannicola, Gaia" uniqKey="Giannicola G" first="Gaia" last="Giannicola">Gaia Giannicola</name><name sortKey="Lucchiari, Claudio" sort="Lucchiari, Claudio" uniqKey="Lucchiari C" first="Claudio" last="Lucchiari">Claudio Lucchiari</name><name sortKey="Marceglia, Sara" sort="Marceglia, Sara" uniqKey="Marceglia S" first="Sara" last="Marceglia">Sara Marceglia</name><name sortKey="Pacchetti, Claudio" sort="Pacchetti, Claudio" uniqKey="Pacchetti C" first="Claudio" last="Pacchetti">Claudio Pacchetti</name><name sortKey="Porta, Mauro" sort="Porta, Mauro" uniqKey="Porta M" first="Mauro" last="Porta">Mauro Porta</name><name sortKey="Pravettoni, Gabriella" sort="Pravettoni, Gabriella" uniqKey="Pravettoni G" first="Gabriella" last="Pravettoni">Gabriella Pravettoni</name><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><name sortKey="Servello, Domenico" sort="Servello, Domenico" uniqKey="Servello D" first="Domenico" last="Servello">Domenico Servello</name></noCountry><country name="Italie"><region name="Lombardie"><name sortKey="Rosa, Manuela" sort="Rosa, Manuela" uniqKey="Rosa M" first="Manuela" last="Rosa">Manuela Rosa</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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